Basal Ganglia Mechanical Stiffness is Associated with Fluid Intelligence in Amnestic Mild Cognitive Impairment
Mary K Kramer, Peyton L Delgorio, Alexa M Diano, Grace McIlvain, Kyra E Twohy, Olivia M Bailey, Matthew L Cohen, Alyssa M Lanzi, Christopher R Martens, Curtis L Johnson · 2025
Read Basal Ganglia Mechanical Stiffness is Associated with Fluid Intelligence in Amnestic Mild Cognitive Impairment by Mary K Kramer, Peyton L Delgorio, Alexa M Diano, Grace McIlvain, Kyra E Twohy, Olivia M Bailey, Matthew L Cohen, Alyssa M Lanzi, Christopher R Martens, Curtis L Johnson (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713545.txt.
Description
Mary Kramer and co-authors use vibration-based MRI scans to compare brain stiffness in people with early memory impairment and healthy peers, in a study from 2025. Magnetic resonance elastography shakes the brain gently and reads how stiff each region is. The team scanned 67 healthy adults and 34 with amnestic mild cognitive impairment, focusing on the basal ganglia.
The impaired group had stiffer basal ganglia, 2.99 versus 2.89 kilopascals. Within that group, stiffer tissue tracked with better fluid reasoning scores, a link absent in healthy peers. The authors suggest stiffness may capture parts of the disease process that standard scans miss. They present the method as a sensitive window on brain health in aging and early decline.
Catalog record
| CREATOR | Mary K Kramer, Peyton L Delgorio, Alexa M Diano, Grace McIlvain, Kyra E Twohy, Olivia M Bailey, Matthew L Cohen, Alyssa M Lanzi, Christopher R Martens, Curtis L Johnson |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |