Improving the Clinical Translation of Circadian Clock Dysfunction Treatments in Alzheimer’s Disease with Nanoformulations
Marion Le Meur, Paolo Blasi, Valle Palomo Ruiz · 2025
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Description
Le Meur and co-authors test tiny drug carriers meant to fix body-clock problems in Alzheimer's disease, in this 2025 paper. About half of patients have sleep trouble, and a broken clock in the brain can speed the disease. Drugs for the clock often fail in patients because they cannot cross into the brain well.
The team packed melatonin into several kinds of nanoparticles, some coated to slip past the blood-brain barrier. They measured particle size, charge, drug load, and release speed. The best carriers were picked with a lab test that mimics the barrier. Timed release could one day restore daily rhythms in patients.
Catalog record
| CREATOR | Marion Le Meur, Paolo Blasi, Valle Palomo Ruiz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |