Characterization of GPR3 function in astrocytes in a preclinical AD mouse model
Carlos Alberto Ayhllon Osorio, Diego Rolando Hernandez Espinosa, Yunhong Huang, Thais Rafael Guimarães, Amantha Thathiah · 2025
Read Characterization of GPR3 function in astrocytes in a preclinical AD mouse model by Carlos Alberto Ayhllon Osorio, Diego Rolando Hernandez Espinosa, Yunhong Huang, Thais Rafael Guimarães, Amantha Thathiah (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713493.txt.
Description
Carlos Alberto Ayhllon Osorio and co-authors present a conference report, published in 2025, on a receptor called GPR3 in star shaped brain support cells. GPR3 has been tied to amyloid beta, the protein that builds up in Alzheimer's disease. Removing the gene for GPR3 lowered plaque load in mice, but it also raised anxiety like behavior, so a finer approach is needed.
Earlier work from the same lab found a way to block only one of the receptor's two signaling routes, keeping the other intact. Since astrocytes carry more GPR3 than nerve cells do, the team is now mapping its role in those cells in a mouse model. Gene reads and cell sorting across disease stages form the core of the plan.
Catalog record
| CREATOR | Carlos Alberto Ayhllon Osorio, Diego Rolando Hernandez Espinosa, Yunhong Huang, Thais Rafael Guimarães, Amantha Thathiah |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |