Translating high throughput screens in C elegans and microglia to humans with Medicare data to repurpose drugs to treat Alzheimer’s disease
Rachel R Litke, Arushi Arora, Yihan Wang, Melissa D Aldridge, Fred C Ko, Sven Sandin, Mary Sano, Abraham Reichenberg, Charles V Mobbs · 2025
Read Translating high throughput screens in C elegans and microglia to humans with Medicare data to repurpose drugs to treat Alzheimer’s disease by Rachel R Litke, Arushi Arora, Yihan Wang, Melissa D Aldridge, Fred C Ko, Sven Sandin, Mary Sano, Abraham Reichenberg, Charles V Mobbs (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713460.txt.
Description
Litke and co-authors lay out a plan to find new uses for old drugs against Alzheimer's disease, in this 2025 paper. Their search starts with fast screens in worms and in immune cells grown in dishes. Hits from those screens then get checked in records from real patients.
The worm screen flags drugs that cut toxic protein harm, and the cell screen flags drugs that calm inflammation. Fifty approved drugs passed both screens. The team will test them in Medicare records for a million older adults followed for ten years. Drugs whose users fare better could move toward trials far faster than brand-new drugs.
Catalog record
| CREATOR | Rachel R Litke, Arushi Arora, Yihan Wang, Melissa D Aldridge, Fred C Ko, Sven Sandin, Mary Sano, Abraham Reichenberg, Charles V Mobbs |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |