A multiple cohort study exploring the influence of partial volume correction on age and sex effects on tau PET imaging
Diana A Hobbs, Shaney Flores, Sarah J Keefe, John C Morris, Tammie LS Benzinger, Brian A Gordon · 2025
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Description
Diana A Hobbs and co-authors check whether a common image-cleaning step changes what brain scans seem to say about aging and sex. The scans track tau, a protein tied to Alzheimer's disease, in people with no amyloid buildup. A correction for blur, called partial volume correction, is meant to sharpen the signal, but labs apply it in different ways.
Using two large cohorts, the team measured tau in forty-two brain regions with and without the fix. Within each cohort, age and sex patterns stayed broadly similar either way. Across cohorts, though, the uncured data agreed strongly while the corrected data stopped matching. The authors warn that the choice of correction can create or erase findings, especially where true signal is faint.
Catalog record
| CREATOR | Diana A Hobbs, Shaney Flores, Sarah J Keefe, John C Morris, Tammie LS Benzinger, Brian A Gordon |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |