Association of Chronic pain with Alzheimer’s‐related brain structure and plasma biomarkers in older men
Tyler R. Bell, Carol E. Franz, Christine Fennema‐Notestine, Matthew S. Panizzon, Michael J. Lyons, Jeremy A. Elman, William S. Kremen · 2025
Read Association of Chronic pain with Alzheimer’s‐related brain structure and plasma biomarkers in older men by Tyler R. Bell, Carol E. Franz, Christine Fennema‐Notestine, Matthew S. Panizzon, Michael J. Lyons, Jeremy A. Elman, William S. Kremen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713416.txt.
Description
Tyler Bell and six colleagues link long-term pain to early Alzheimer's-style changes in older men's brains, in a 2025 study. In mice, chronic pain drives tau buildup and shrinkage of the hippocampus. The team asked whether the same pairing shows up in humans, using a twin aging study with waves at average ages fifty-six, sixty-two, and sixty-eight.
At the third wave, 424 men received brain scans and blood tests. Men whose moderate-to-severe pain persisted across waves had smaller hippocampi. A brainstem hub called the locus coeruleus, where tau gathers earliest, also showed weaker integrity in its front portion. Blood levels of total tau and individual amyloid fragments ran higher, though the amyloid ratio did not differ. The authors read pain as a possible early contributor to Alzheimer's risk, not just a symptom's companion.
Catalog record
| CREATOR | Tyler R. Bell, Carol E. Franz, Christine Fennema‐Notestine, Matthew S. Panizzon, Michael J. Lyons, Jeremy A. Elman, William S. Kremen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |