Genetic evidence supports therapeutic hypothesis of increasing progranulin levels for Alzheimer’s Disease
Chloe Robins, John Eicher, Qin Wang, Jimmy Liu, Dongjing Liu, Thomas Richardson, Jonathan Davitte, David J. Pulford, Padhraig Gormley, Erik D. Ingelsson, Robert A. Scott, Sanjay Kumar, Chun‐ Fang Xu · 2025
Read Genetic evidence supports therapeutic hypothesis of increasing progranulin levels for Alzheimer’s Disease by Chloe Robins, John Eicher, Qin Wang, Jimmy Liu, Dongjing Liu, Thomas Richardson, Jonathan Davitte, David J. Pulford, Padhraig Gormley, Erik D. Ingelsson, Robert A. Scott, Sanjay Kumar, Chun‐ Fang Xu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713365.txt.
Description
Chloe Robins and a large team present genetic evidence on raising progranulin levels as a treatment idea for Alzheimer's disease, in a 2025 paper. Changes in the gene for progranulin cause or raise risk for several brain diseases. That link has made the protein a target of interest.
The team combined gene data with protein data from large biobanks and brain-fluid cohorts. Several lines of evidence pointed the same way: higher progranulin went with lower risk of Alzheimer's and dementia. They also mapped genes that affect progranulin levels, with one receptor gene showing the strongest signal. The results support testing ways to raise the protein.
Catalog record
| CREATOR | Chloe Robins, John Eicher, Qin Wang, Jimmy Liu, Dongjing Liu, Thomas Richardson, Jonathan Davitte, David J. Pulford, Padhraig Gormley, Erik D. Ingelsson, Robert A. Scott, Sanjay Kumar, Chun‐ Fang Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |