Associations Between Choroid Plexus Integrity and Cognitive Decline in Aging: Insights from Advanced MRI Analysis
Zhaoyuan Gong, Murat Bilgel, Mary E Faulkner, Jonghyun Bae, John P Laporte, Alex Guo, Susan M. Resnick, Josephine M. Egan, Mustapha Bouhrara · 2025
Read Associations Between Choroid Plexus Integrity and Cognitive Decline in Aging: Insights from Advanced MRI Analysis by Zhaoyuan Gong, Murat Bilgel, Mary E Faulkner, Jonghyun Bae, John P Laporte, Alex Guo, Susan M. Resnick, Josephine M. Egan, Mustapha Bouhrara (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713363.txt.
Description
Zhaoyuan Gong and co-authors linked this 2025 brain structure to memory decline in aging. The choroid plexus sits in the brain's fluid chambers, making spinal fluid, guarding the blood-fluid barrier, and clearing waste. When its tissue degrades, the brain's inner balance suffers. Such changes appear in aging and in diseases like Alzheimer's.
The team scanned 116 cognitively healthy adults with advanced MRI that measures tissue quality, not just size. Across 320 visits, they tracked memory, attention, and speed alongside plexus volume and tissue measures. The design tests whether plexus wear foreshadows thinking decline before symptoms show. If so, this small, scannable structure could become an early-warning marker for brain aging.
Catalog record
| CREATOR | Zhaoyuan Gong, Murat Bilgel, Mary E Faulkner, Jonghyun Bae, John P Laporte, Alex Guo, Susan M. Resnick, Josephine M. Egan, Mustapha Bouhrara |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |