Harmonized Tractometry Visualizes Alzheimer’s Disease Effects on the Brain’s White Matter Tract Microstructure
Bramsh Q Chandio, Julio E Villalon Reina, Talia M Nir, Sophia I Thomopoulos, Yixue Feng, Sebastian M Benavidez, Neda Jahanshad, Jaroslaw Harezlak, Eleftherios Garyfallidis, Paul M Thompson · 2025
Read Harmonized Tractometry Visualizes Alzheimer’s Disease Effects on the Brain’s White Matter Tract Microstructure by Bramsh Q Chandio, Julio E Villalon Reina, Talia M Nir, Sophia I Thomopoulos, Yixue Feng, Sebastian M Benavidez, Neda Jahanshad, Jaroslaw Harezlak, Eleftherios Garyfallidis, Paul M Thompson (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713354.txt.
Description
Bramsh Chandio and co-authors extend a tractometry pipeline so diffusion MRI data from many scanners can be pooled to study Alzheimer's disease. Their BUAN method profiles white matter tracts point by point, and a harmonization step based on ComBat now removes site and scanner effects at each point. Data came from 730 people in the ADNI3 study, scanned under seven protocols.
Thirty-eight tracts were extracted and four microstructure measures were profiled along each. Harmonized maps showed effects of mild cognitive impairment and Alzheimer's disease spread through specific tracts, such as the left cingulum and right arcuate fasciculus. Pooling across sites thus gives a sharper local picture of tract damage.
Catalog record
| CREATOR | Bramsh Q Chandio, Julio E Villalon Reina, Talia M Nir, Sophia I Thomopoulos, Yixue Feng, Sebastian M Benavidez, Neda Jahanshad, Jaroslaw Harezlak, Eleftherios Garyfallidis, Paul M Thompson |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |