The integration of epigenomic and transcriptomic sequencing data reveals cell‐specific Bexarotene‐induced transcriptional activity in APP/PS1 mouse brain
Yi Lu, Carolina Saibro‐Girardi, Nicholas F Fitz, Iliya Lefterov, Radosveta Koldamova · 2025
Read The integration of epigenomic and transcriptomic sequencing data reveals cell‐specific Bexarotene‐induced transcriptional activity in APP/PS1 mouse brain by Yi Lu, Carolina Saibro‐Girardi, Nicholas F Fitz, Iliya Lefterov, Radosveta Koldamova (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713328.txt.
Description
Yi Lu and co-authors study how a drug called bexarotene changes gene activity in mouse brains, in this 2025 paper. The mice carry genes that mimic Alzheimer's disease. Earlier work found that the drug helped the mice clear amyloid and think better.
The team treated the mice with the drug or a plain control, then read gene activity cell by cell. They also mapped how open or closed each cell's DNA was, using two single-cell methods. Joining the two maps shows which cell types respond to the drug and which gene networks switch on. The results may help explain how the drug protects the brain.
Catalog record
| CREATOR | Yi Lu, Carolina Saibro‐Girardi, Nicholas F Fitz, Iliya Lefterov, Radosveta Koldamova |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |