Distinct Spatial Patterns for White Matter Microstructure Changes in an Aging and Alzheimer's Disease Cohort
Jianqiao Tian, Sheelakumari Raghavan, Petrice M Cogswell, Robert I Reid, Scott A Przybelski, Christopher G Schwarz, Jonathan Graff‐Radford, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri · 2025
Read Distinct Spatial Patterns for White Matter Microstructure Changes in an Aging and Alzheimer's Disease Cohort by Jianqiao Tian, Sheelakumari Raghavan, Petrice M Cogswell, Robert I Reid, Scott A Przybelski, Christopher G Schwarz, Jonathan Graff‐Radford, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713326.txt.
Description
Jianqiao Tian and co-authors searched for distinct patterns of white matter change in aging and Alzheimer disease in 2025. White matter harm from vessel and nerve disease can weaken thinking. The team guessed that more than one pattern of change exists and can be found from scan data.
They used a clustering method on diffusion scans from more than eleven hundred people in Mayo Clinic cohorts. Two scan measures captured fiber packing and free water in fifty-five regions. A subset of regions changed steadily with disease stage. Fiber loss clustered in the temporal lobe, while free water rose mainly in frontal and deep regions. Two stable patterns of progression emerged from the method.
Catalog record
| CREATOR | Jianqiao Tian, Sheelakumari Raghavan, Petrice M Cogswell, Robert I Reid, Scott A Przybelski, Christopher G Schwarz, Jonathan Graff‐Radford, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |