Association between Default Mode Network Connectivity Compared Between Two Tau Tracers (Flortaucipir vs. MK6240) – HEAD Study
Helmet T. Karim, Guilherme Povala, Guilherme Bauer‐Negrini, Firoza Z Lussier, Belen Pascual, Brian A. Gordon, Val J. Lowe, Hwamee Oh, David N. soleimani‐meigooni, Pedro Rosa‐Neto, William J. Jagust, William E Klunk, Suzanne L. Baker, Tharick Ali Pascoal · 2025
Read Association between Default Mode Network Connectivity Compared Between Two Tau Tracers (Flortaucipir vs. MK6240) – HEAD Study by Helmet T. Karim, Guilherme Povala, Guilherme Bauer‐Negrini, Firoza Z Lussier, Belen Pascual, Brian A. Gordon, Val J. Lowe, Hwamee Oh, David N. soleimani‐meigooni, Pedro Rosa‐Neto, William J. Jagust, William E Klunk, Suzanne L. Baker, Tharick Ali Pascoal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713324.txt.
Description
Helmet Karim and co-authors compare two tau imaging tracers against brain network connectivity in Alzheimer's research. Their 2025 study recruits people across the range of cognitive health and scans them at rest, plus with both tracers, which light up the tau tangles of Alzheimer's disease. The default mode network, a set of regions active at rest, is known to falter as amyloid and tau build.
Tau is thought to strike a belt of memory regions tied to that network, including the amygdala and hippocampal neighbors. The team asks whether network strength links to global tau load the same way under each tracer. A head-to-head read helps trials choose their imaging yardstick.
Catalog record
| CREATOR | Helmet T. Karim, Guilherme Povala, Guilherme Bauer‐Negrini, Firoza Z Lussier, Belen Pascual, Brian A. Gordon, Val J. Lowe, Hwamee Oh, David N. soleimani‐meigooni, Pedro Rosa‐Neto, William J. Jagust, William E Klunk, Suzanne L. Baker, Tharick Ali Pascoal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |