Unveiling a role of the Gβγ/PLCβ3 signaling pathway on APP endolysosomal re‐distribution and Aβ‐induced amyloidogenesis
Romina soledad Almirón, Magdalena Antonino, Paula Marmo, Alfredo Lorenzo, Elena Anahi Bignante · 2025
Read Unveiling a role of the Gβγ/PLCβ3 signaling pathway on APP endolysosomal re‐distribution and Aβ‐induced amyloidogenesis by Romina soledad Almirón, Magdalena Antonino, Paula Marmo, Alfredo Lorenzo, Elena Anahi Bignante (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713320.txt.
Description
Romina Soledad Almirón and co-authors probe a signaling path that may drive amyloid buildup in Alzheimer's disease. Amyloid beta buildup is a key source of harm in the disease, and amyloid itself can push cells to make more of it. Earlier work showed amyloid oligomers raise levels of the APP protein and the BACE1 enzyme inside Rab11 endosomes.
In their 2025 paper, the team tests the role of the G beta gamma and PLC beta 3 pathway in that shift. They tracked tagged APP in cultured cells, measured uptake rates, and used high-resolution imaging in rat neurons and human neurons grown from stem cells. Blocking the pathway with the drug gallein was one of the tools used to test cause and effect.
Catalog record
| CREATOR | Romina soledad Almirón, Magdalena Antonino, Paula Marmo, Alfredo Lorenzo, Elena Anahi Bignante |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |