Longitudinal cortical atrophy in cases of AT concordance and discordance
Konstantinos Ioannou, Rosaleena Mohanty, Konstantinos Poulakis, Antoine Leuzy, J‐Sebastian Muehlboeck, Elena Rodriguez‐Vieitez, Eric Westman, Konstantinos Chiotis · 2025
Read Longitudinal cortical atrophy in cases of AT concordance and discordance by Konstantinos Ioannou, Rosaleena Mohanty, Konstantinos Poulakis, Antoine Leuzy, J‐Sebastian Muehlboeck, Elena Rodriguez‐Vieitez, Eric Westman, Konstantinos Chiotis (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713317.txt.
Description
Ioannou and co-authors follow brain shrinkage in people whose amyloid and tau scans agree or clash, in this 2025 paper. When both scans are positive, decline is expected in Alzheimer's disease. What drives tissue loss when only one is positive is less settled.
The team picked three hundred forty-nine people from a national dataset, each with both scan types, repeat MRI, and at least two years of thinking tests. People were grouped by scan status and by fast or slow decline. Models then tracked thickness change across the brain's surface for each group. The results help show which protein drives harm when the two disagree.
Catalog record
| CREATOR | Konstantinos Ioannou, Rosaleena Mohanty, Konstantinos Poulakis, Antoine Leuzy, J‐Sebastian Muehlboeck, Elena Rodriguez‐Vieitez, Eric Westman, Konstantinos Chiotis |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |