Characterization of the heterogeneity of amyloid‐PET‐negative patients with a clinical diagnosis of sporadic early‐onset AD: an FDG‐PET study in the LEADS cohort
Julien Lagarde, Daniel R. Schonhaut, Piyush Maiti, Jiaxiuxiu Zhang, David N. soleimani‐meigooni, Ehud Zeltzer, Charles Windon, Dustin B. Hammers, Jeffrey L. Dage, Kelly N. Nudelman, Ani Eloyan, Robert A. Koeppe, Maria C. Carrillo, Alexandra Touroutoglou, Prashanthi Vemuri, Bradford C. Dickerson, Lia · 2025
Read Characterization of the heterogeneity of amyloid‐PET‐negative patients with a clinical diagnosis of sporadic early‐onset AD: an FDG‐PET study in the LEADS cohort by Julien Lagarde, Daniel R. Schonhaut, Piyush Maiti, Jiaxiuxiu Zhang, David N. soleimani‐meigooni, Ehud Zeltzer, Charles Windon, Dustin B. Hammers, Jeffrey L. Dage, Kelly N. Nudelman, Ani Eloyan, Robert A. Koeppe, Maria C. Carrillo, Alexandra Touroutoglou, Prashanthi Vemuri, Bradford C. Dickerson, Lia (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713310.txt.
Description
Lagarde and co-authors study younger Alzheimer's patients whose amyloid scans come back negative, in this 2025 paper. About a quarter of such patients in a large early-onset study lack the amyloid the diagnosis implies. Some other cause must explain their symptoms.
Seventy-four patients had a second scan that shows how active brain areas are. The team sorted scans as normal or low-activity using strict data rules and a matched control group. They then compared the two patient groups on health and personal traits. The split may reveal which patients have true Alzheimer's disease and which have look-alike conditions that need different care.
Catalog record
| CREATOR | Julien Lagarde, Daniel R. Schonhaut, Piyush Maiti, Jiaxiuxiu Zhang, David N. soleimani‐meigooni, Ehud Zeltzer, Charles Windon, Dustin B. Hammers, Jeffrey L. Dage, Kelly N. Nudelman, Ani Eloyan, Robert A. Koeppe, Maria C. Carrillo, Alexandra Touroutoglou, Prashanthi Vemuri, Bradford C. Dickerson, Lia |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |