Associations between Amyloid, Cardiovascular Risk, and Cognitive Function in Korean Older Adults: Insights from the KBASE Cohort
Soumilee Chaudhuri, Desarae A Dempsey, Yen‐Ning Huang, Sha Cao, Evgeny J Chumin, Hannah Craft, Paul K Crane, Shubhabrata Mukherjee, Seo‐Eun Choi, Michael L Lee, Phoebe Scollard, Jesse Mez, Emily H Trittschuh, Brandon S Klinedinst, Connie Nakano, Timothy J Hohman, Dahyun Yi, Min Soo Byun, Shannon L R · 2025
Read Associations between Amyloid, Cardiovascular Risk, and Cognitive Function in Korean Older Adults: Insights from the KBASE Cohort by Soumilee Chaudhuri, Desarae A Dempsey, Yen‐Ning Huang, Sha Cao, Evgeny J Chumin, Hannah Craft, Paul K Crane, Shubhabrata Mukherjee, Seo‐Eun Choi, Michael L Lee, Phoebe Scollard, Jesse Mez, Emily H Trittschuh, Brandon S Klinedinst, Connie Nakano, Timothy J Hohman, Dahyun Yi, Min Soo Byun, Shannon L R (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713278.txt.
Description
Soumilee Chaudhuri and a large team of co-authors present a 2025 study from a Korean brain aging cohort on how heart risk and amyloid plaques combine to affect thinking. The cohort, called KBASE, follows older adults across the Alzheimer's spectrum. The team split 526 participants into four groups by cardiovascular risk score and by whether brain amyloid was present.
Cognition differed across the groups in every domain tested, including memory, language, and executive function. Even without amyloid, cognitively normal elders with high heart risk scored notably worse on memory than their low-risk peers. Four years of follow-up tracked how the gaps evolved. The authors argue that vascular care may protect memory even before Alzheimer's pathology appears.
Catalog record
| CREATOR | Soumilee Chaudhuri, Desarae A Dempsey, Yen‐Ning Huang, Sha Cao, Evgeny J Chumin, Hannah Craft, Paul K Crane, Shubhabrata Mukherjee, Seo‐Eun Choi, Michael L Lee, Phoebe Scollard, Jesse Mez, Emily H Trittschuh, Brandon S Klinedinst, Connie Nakano, Timothy J Hohman, Dahyun Yi, Min Soo Byun, Shannon L R |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |