Potential Relative Effect of Intensive Systolic Blood Pressure Control on Preventing White Matter Damage Across Age Groups
Jeremy J. Pruzin, Kyle C Kern, David M. Reboussin, William C. Cushman, Aditi Gupta, Clinton B. Wright, Jeff D. Williamson, Pierre N. Tariot, Ilya M. Nasrallah, Nicholas M. Pajewski · 2025
Read Potential Relative Effect of Intensive Systolic Blood Pressure Control on Preventing White Matter Damage Across Age Groups by Jeremy J. Pruzin, Kyle C Kern, David M. Reboussin, William C. Cushman, Aditi Gupta, Clinton B. Wright, Jeff D. Williamson, Pierre N. Tariot, Ilya M. Nasrallah, Nicholas M. Pajewski (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713270.txt.
Description
Jeremy Pruzin and co-authors revisit a major blood pressure trial in a 2025 paper. The SPRINT trial showed that lowering systolic pressure hard slows damage to the brain's white matter. The team asked whether that protection is stronger in younger patients than in older ones.
A subgroup with brain scans at the start and after about four years was split by age. The intensive group reached much lower pressure than the standard group. White matter damage grew least, relative to standard care, in patients under 65, with a 73 percent cut in progression. The cut shrank with age, reaching about 20 percent over 75. The trend was not statistically firm, the authors note, and a second scan measure told a similar story.
Catalog record
| CREATOR | Jeremy J. Pruzin, Kyle C Kern, David M. Reboussin, William C. Cushman, Aditi Gupta, Clinton B. Wright, Jeff D. Williamson, Pierre N. Tariot, Ilya M. Nasrallah, Nicholas M. Pajewski |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |