Microglia density measured by TSPO PET across amyloid positivity and clinical variants
Hannah M Houlihan, Aubrey S Johnson, Anna C Smith, Diana S Guzmán, Amarachukwu Okafor, Lauren B Heuer, Daniel Talmasov, Ndubisi Chikwem, Dina S Dass, James M Noble, William C Kreisl, Scott A Small, Patrick J Lao · 2025
Read Microglia density measured by TSPO PET across amyloid positivity and clinical variants by Hannah M Houlihan, Aubrey S Johnson, Anna C Smith, Diana S Guzmán, Amarachukwu Okafor, Lauren B Heuer, Daniel Talmasov, Ndubisi Chikwem, Dina S Dass, James M Noble, William C Kreisl, Scott A Small, Patrick J Lao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713120.txt.
Description
Houlihan and colleagues used in 2025 PET imaging to measure microglia density in people with and without Alzheimer's disease variants. Microglia are the brain's immune cells, and their activity may follow amyloid and tau spread. Participants had amyloid, tau, and TSPO scans. The TSPO signal marks microglia density. Groups included typical Alzheimer's, a visual variant, and impaired people without amyloid.
Amyloid-positive groups showed raised microglia signals in regions matching their tau patterns. The impaired amyloid-negative group showed the strongest rises in limbic regions. The authors suggest non-Alzheimer processes, or limbic inflammation itself, can drive impairment when amyloid and tau are low.
Catalog record
| CREATOR | Hannah M Houlihan, Aubrey S Johnson, Anna C Smith, Diana S Guzmán, Amarachukwu Okafor, Lauren B Heuer, Daniel Talmasov, Ndubisi Chikwem, Dina S Dass, James M Noble, William C Kreisl, Scott A Small, Patrick J Lao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |