New anti‐tau VHH: from biophysical characterization to proof‐of‐concept in experimental models
Clément Danis, Raphaelle Caillierez, Justine Mortelecque, Séverine Bégard, Orgeta Zejneli, Jean‐Christophe Rain, Morvane Colin, Elian Dupre, Isabelle Landrieu, Luc Buee · 2025
Read New anti‐tau VHH: from biophysical characterization to proof‐of‐concept in experimental models by Clément Danis, Raphaelle Caillierez, Justine Mortelecque, Séverine Bégard, Orgeta Zejneli, Jean‐Christophe Rain, Morvane Colin, Elian Dupre, Isabelle Landrieu, Luc Buee (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713117.txt.
Description
Clément Danis and co-authors craft tiny antibody fragments, called VHHs, that hunt tau protein inside brain cells. Tau clumps in a family of brain diseases, and its microtubule-binding region drives the clumping. The team screened a synthetic library of humanized VHHs and picked a dozen that grip tau near or inside that region.
Three leads went forward for deep study. One, named Z70, aims at the PHF6 spot and curbed tau seeding in cell tests and in animals dosed by virus carriers. Given by AAV vectors, Z70 proved safe in normal mice and helpful in mice bred for tau disease. A second fragment, H3-2, works by a distinct route the authors discuss. The set forms a pipeline of candidate tau drugs.
Catalog record
| CREATOR | Clément Danis, Raphaelle Caillierez, Justine Mortelecque, Séverine Bégard, Orgeta Zejneli, Jean‐Christophe Rain, Morvane Colin, Elian Dupre, Isabelle Landrieu, Luc Buee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |