Exploring Sex‐Specific Accelerated Hippocampal Atrophy Across AD Stages beyond APOE‐e4 Assessment in Genetic Risk Evaluation
Tavia E Evans, Natalia Vilor‐Tejedor, Albert Rodrigo, Patricia Genius, Blanca Rodríguez‐Fernández, Federica Anastasi, Arcadi Navarro, Hieab HH Adams, Juan Domingo Gispert · 2025
Read Exploring Sex‐Specific Accelerated Hippocampal Atrophy Across AD Stages beyond APOE‐e4 Assessment in Genetic Risk Evaluation by Tavia E Evans, Natalia Vilor‐Tejedor, Albert Rodrigo, Patricia Genius, Blanca Rodríguez‐Fernández, Federica Anastasi, Arcadi Navarro, Hieab HH Adams, Juan Domingo Gispert (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713106.txt.
Description
Tavia E Evans and co-authors present a 2025 study of genes, sex, and shrinkage of the hippocampus, a brain area central to memory. The team asked whether a person's inherited risk for Alzheimer's disease speeds up that shrinkage, and whether the effect differs between women and men and across disease stages.
They followed 1,051 people in the ADNI cohort with gene data and repeat scans over up to eight years. Risk scores were built with and without the APOE gene region, which is known to raise risk. The study tests how much of the gene effect on brain change runs through that one region alone.
Catalog record
| CREATOR | Tavia E Evans, Natalia Vilor‐Tejedor, Albert Rodrigo, Patricia Genius, Blanca Rodríguez‐Fernández, Federica Anastasi, Arcadi Navarro, Hieab HH Adams, Juan Domingo Gispert |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |