Fatal Iatrogenic Cerebral Amyloid‐Related Encephalitis in a woman treated with lecanemab for Alzheimer’s disease
Elena Solopova · 2025
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Description
Elena Solopova reports a 2025 case study of a seventy-nine-year-old woman who died after treatment with lecanemab, a drug for Alzheimer's disease given by infusion. After her third dose, spaced two weeks apart, she had a seizure, lost language, and grew steadily worse despite strong treatment. She died five days later.
Scans after death showed wide bleeding spots in several brain lobes, far more than before the trial. Autopsy found severe amyloid in vessel walls, inflamed vessels, and two copies of a gene form tied to higher risk. Solopova concludes the likely cause of death was severe brain swelling and inflammation linked to amyloid.
Catalog record
| CREATOR | Elena Solopova |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |