Detecting amyloid positivity from MRI scans using comprehensible convolutional neural networks
Fedor Levin, Qingyue Li, Devesh Singh, Katharina Buerger, Klaus Fliessbach, Michael T. Heneka, Luca Kleineidam, Christoph Laske, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Michael Wagner, Jens Wiltfang, Emrah Düzel, Frank Jessen, Stefan Teipel, M · 2025
Read Detecting amyloid positivity from MRI scans using comprehensible convolutional neural networks by Fedor Levin, Qingyue Li, Devesh Singh, Katharina Buerger, Klaus Fliessbach, Michael T. Heneka, Luca Kleineidam, Christoph Laske, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Michael Wagner, Jens Wiltfang, Emrah Düzel, Frank Jessen, Stefan Teipel, M (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713062.txt.
Description
A standard brain scan might reveal who carries amyloid, the protein clump tied to Alzheimer's disease, without a costly PET scan. Fedor Levin and co-authors trained a neural network to make that call from MRI scans. Training used one thousand four hundred sixty-one people from a large study, classed from healthy to dementia. About forty-six percent were amyloid positive by PET. The network was built so its choices can be inspected, not just read off.
Ten rounds of cross-checking tested how steady the model was. An explainable model matters because doctors need to see why a scan was flagged. If such screening holds up, trials could pre-pick likely amyloid carriers cheaply. It could also speed case finding for new treatments.
Catalog record
| CREATOR | Fedor Levin, Qingyue Li, Devesh Singh, Katharina Buerger, Klaus Fliessbach, Michael T. Heneka, Luca Kleineidam, Christoph Laske, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Michael Wagner, Jens Wiltfang, Emrah Düzel, Frank Jessen, Stefan Teipel, M |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |