Spatial transcriptomic of hippocampal subfield‐specific pathology in Alzheimer’s disease and Primary Age‐Related Tauopathy (PART)
Di Wu, Qilei Zhang, Anqi Liu, Yun Gong, Li Tianying, Zhengwu Xiao, Hongmei Xiao, Kuan‐Jui Su, Chuan Qiu, Hui Shen, Xiaoxin Yan, Hong‐Wen Deng · 2025
Read Spatial transcriptomic of hippocampal subfield‐specific pathology in Alzheimer’s disease and Primary Age‐Related Tauopathy (PART) by Di Wu, Qilei Zhang, Anqi Liu, Yun Gong, Li Tianying, Zhengwu Xiao, Hongmei Xiao, Kuan‐Jui Su, Chuan Qiu, Hui Shen, Xiaoxin Yan, Hong‐Wen Deng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713059.txt.
Description
Di Wu and co-authors build a space map of gene use in the brain's memory hub for two tau ills. The study appeared in 2025. Both ills show tau clumps in that hub, but they split in where the clumps grow and in a second plaque mark. Mind state ties to how much tau sits in the hub.
Tissue came from six adults, two with one ill, three with the other, and one well peer. Space and core gene reads fed the maps. Zone splits were set by group tools and hand marks. The team then read gene shifts by zone and cell type across the three states.
Catalog record
| CREATOR | Di Wu, Qilei Zhang, Anqi Liu, Yun Gong, Li Tianying, Zhengwu Xiao, Hongmei Xiao, Kuan‐Jui Su, Chuan Qiu, Hui Shen, Xiaoxin Yan, Hong‐Wen Deng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |