A diffusion kurtosis MRI signature of subjective cognitive decline
Ryn Flaherty, Yu Veronica Sui, Mu Li, Ana Ardelean, Henry Rusinek, Arjun V Masurkar, Mariana Lazar · 2025
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Description
Ryn Flaherty and co-authors search for a brain imaging signature of subjective cognitive decline. Their 2025 paper studies people who feel their memory slipping while tests still score them as normal. Such complaints can precede Alzheimer's disease, and fluid markers have proven weaker than imaging at forecasting decline.
The team scanned three hundred sixteen cognitively normal adults over fifty-five, one hundred twenty-three of them with memory complaints. Several diffusion models were fit to white and gray matter, alongside measures of volume and cortical thickness. Gray matter diffusion has been little studied in this group, so the work tests whether it carries its own signal. Regional averages were compared between groups to find where the signature lives.
Catalog record
| CREATOR | Ryn Flaherty, Yu Veronica Sui, Mu Li, Ana Ardelean, Henry Rusinek, Arjun V Masurkar, Mariana Lazar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |