Critical Path for Alzheimer’s Disease (CPAD) Consortium: Data‐Driven Solutions for Clinical Trial Design and Informed Decision Making
Sudhir Sivakumaran, Eileen Priest, Corissa Lau, Michael C Irizarry, Yashmin Karten · 2025
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Description
Sudhir Sivakumaran and co-authors describe a consortium pooling Alzheimer trial data to build better trial tools. The group, CPAD, gives drug makers, regulators, academics, and patient advocates a neutral table. Members share patient-level data and brain scans from past trials, which the consortium cleans and standardizes for joint modeling.
By late 2023 the storehouse held seventy-three studies and over one hundred thousand patient records, rich in biomarker data. Models built on it trace how the disease progresses and power simulators that test trial designs before they run. Two joint projects aim to harmonize a key brain-scan measure across tracers and to judge whether it can stand in for clinical benefit. The authors say shared data speeds safer decisions in a field littered with failed trials.
Catalog record
| CREATOR | Sudhir Sivakumaran, Eileen Priest, Corissa Lau, Michael C Irizarry, Yashmin Karten |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |