Tau vaccines differentially target tau pathologies in Alzheimer’s disease and primary tauopathies
Jonathan P Hulse, Madelin Whelpley, Nicole M Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaskar · 2025
Read Tau vaccines differentially target tau pathologies in Alzheimer’s disease and primary tauopathies by Jonathan P Hulse, Madelin Whelpley, Nicole M Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaskar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712858.txt.
Description
Jonathan P Hulse and co-authors describe a 2025 study of vaccines aimed at tau, a protein that builds up in tangles in Alzheimer's disease and in related brain diseases called tauopathies. Each vaccine trains the immune system to spot tau at one exact site where it carries extra phosphate groups.
The team tested blood serum from vaccinated mice on slices of human brain tissue from people who had Alzheimer's disease or one of the related diseases. Serum from each vaccine did stain the tangles, but the pattern differed by site and by disease. The results suggest that a vaccine may need to match the tau form found in each disease.
Catalog record
| CREATOR | Jonathan P Hulse, Madelin Whelpley, Nicole M Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaskar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |