Phase 2 Study Results of Oral ALZ‐801 (Valiltramiprosate) in Early Alzheimer’s Disease Shows Potential Disease Modification Effect: 2‐Year Effect on Plasma Biomarkers, Volumetric MRI, Cognition Outcomes and Clinical Benefit Analysis
John A. Hey, Susan Abushakra, Kaj Blennow, Patrick Kesslak, Jakub Hort, Niels D. Prins, Katerina Sheardova, Jean Schaefer, Adem Albayrak, Winnie Pak, Aidan Power, Martin Tolar · 2025
Read Phase 2 Study Results of Oral ALZ‐801 (Valiltramiprosate) in Early Alzheimer’s Disease Shows Potential Disease Modification Effect: 2‐Year Effect on Plasma Biomarkers, Volumetric MRI, Cognition Outcomes and Clinical Benefit Analysis by John A. Hey, Susan Abushakra, Kaj Blennow, Patrick Kesslak, Jakub Hort, Niels D. Prins, Katerina Sheardova, Jean Schaefer, Adem Albayrak, Winnie Pak, Aidan Power, Martin Tolar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712856.txt.
Description
John A Hey and co-authors report 2025 results from a two-year study of ALZ-801, a daily pill for early Alzheimer's disease in people who carry the APOE4 gene. The pill blocks the forming of harmful amyloid clumps and is now in a larger final-stage trial. This study tracked blood markers, brain scans, and thinking scores over time.
Eighty-four people joined, and seventy finished the two years. A blood marker tied to tau fell by roughly a third or more at every check. Brain shrinkage and test scores were compared against a matched group from a separate long-term study. The authors read the pattern as a sign the pill may slow the disease itself.
Catalog record
| CREATOR | John A. Hey, Susan Abushakra, Kaj Blennow, Patrick Kesslak, Jakub Hort, Niels D. Prins, Katerina Sheardova, Jean Schaefer, Adem Albayrak, Winnie Pak, Aidan Power, Martin Tolar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |