Discovery of dementia type specific biomarkers with untargeted CSF proteomics
Marijke E Stokkel, Lisa Vermunt, Jaco Knol, Sander Piersma, Thang V Pham, Berend Gagestein, Richard R de Goeij de Haas, Afina Willemina Lemstra, Yolande AL Pijnenburg, Pieter Jelle Visser, Betty M Tijms, Charlotte Teunissen, Connie R Jimenez · 2025
Read Discovery of dementia type specific biomarkers with untargeted CSF proteomics by Marijke E Stokkel, Lisa Vermunt, Jaco Knol, Sander Piersma, Thang V Pham, Berend Gagestein, Richard R de Goeij de Haas, Afina Willemina Lemstra, Yolande AL Pijnenburg, Pieter Jelle Visser, Betty M Tijms, Charlotte Teunissen, Connie R Jimenez (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712855.txt.
Description
Marijke E Stokkel and co-authors report a 2025 search for spinal fluid proteins that can tell apart the main diseases that cause dementia. Alzheimer's disease, dementia with Lewy bodies, and frontotemporal dementia can look alike in the clinic, yet they arise from different changes in the brain.
The team measured thousands of proteins in fluid samples from two groups drawn from the Amsterdam Dementia Cohort. They found small sets of proteins whose levels differed for each disease when groups were compared. Such markers, if they hold up, could help doctors name the right disease earlier and match patients to the right trials and care.
Catalog record
| CREATOR | Marijke E Stokkel, Lisa Vermunt, Jaco Knol, Sander Piersma, Thang V Pham, Berend Gagestein, Richard R de Goeij de Haas, Afina Willemina Lemstra, Yolande AL Pijnenburg, Pieter Jelle Visser, Betty M Tijms, Charlotte Teunissen, Connie R Jimenez |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |