Correlations of antemortem [18F]MK‐6240 PET with ROI‐matched postmortem biochemical assessment of total tau and tau phospho‐epitopes pThr181, pSer199, pThr231, and pSer396
Tobey J Betthauser, Eric E Abrahamson, Elena Ruiz De Chavez, Jordan P Teague, Andrew K McVea, Yuetiva Deming, Brooke E Schroeder, Madeleine R Barger, Sterling C Johnson, Sanjay Asthana, Victor L Villemagne, Bradley T Christian, Shahriar Salamat, Milos D Ikonomovic · 2025
Read Correlations of antemortem [18F]MK‐6240 PET with ROI‐matched postmortem biochemical assessment of total tau and tau phospho‐epitopes pThr181, pSer199, pThr231, and pSer396 by Tobey J Betthauser, Eric E Abrahamson, Elena Ruiz De Chavez, Jordan P Teague, Andrew K McVea, Yuetiva Deming, Brooke E Schroeder, Madeleine R Barger, Sterling C Johnson, Sanjay Asthana, Victor L Villemagne, Bradley T Christian, Shahriar Salamat, Milos D Ikonomovic (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712843.txt.
Description
Brain scans with the tracer MK-6240 light up tau tangles in Alzheimer's disease. Tobey Betthauser and co-authors ask what the signal actually binds. They studied four people who had scans in life and donated brain tissue after death. Tissue came from ten regions per case, matched to the scan regions. Lab assays measured total tau and four phosphorylated forms. Death came about 32 months after imaging, on average.
Higher scan signal tracked higher levels of every measured phospho-tau form. The pattern held across regions and cases. Two cases with full Alzheimer's pathology showed the same links in detail. The study ties the tracer's glow to real tau chemistry.
Catalog record
| CREATOR | Tobey J Betthauser, Eric E Abrahamson, Elena Ruiz De Chavez, Jordan P Teague, Andrew K McVea, Yuetiva Deming, Brooke E Schroeder, Madeleine R Barger, Sterling C Johnson, Sanjay Asthana, Victor L Villemagne, Bradley T Christian, Shahriar Salamat, Milos D Ikonomovic |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |