Delivery of incretin receptor agonists to the brain
Elizabeth Rhea · 2025
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Description
Elizabeth Rhea published a research paper in 2025 on how to get a class of diabetes drugs into the brain. The drugs mimic gut hormones and seem to help brain cells, but only if they can reach them. Rhea tested two routes in mice: through the blood, past the brain's tight wall, and up through the nose.
Many, though not all, of the drugs crossed the wall from the blood, and some crossed faster than others. Drugs sent up the nose also spread through the brain, in healthy mice and in a strain bred for Alzheimer's-like changes alike. The results help drug makers pick which of these drugs to test for brain diseases.
Catalog record
| CREATOR | Elizabeth Rhea |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |