The Association between Hepatic fat and Neuroinflammation in Midlife Obesity
Mahsa Dolatshahi, Farzaneh Rahmani, Paul K Commean, Sara Hosseinzadeh Kasani, Mahshid Naghashzadeh, LaKisha Lloyd, Caitlyn Nguyen, Abby McBee‐Kemper, Jake Weeks, Lael Ceriani, Bettina Mittendorfer, Claude Sirlin, Sheng‐Kwei Song, Tammie LS Benzinger, Joseph E Ippolito, John C Morris, Cyrus A Raji · 2025
Read The Association between Hepatic fat and Neuroinflammation in Midlife Obesity by Mahsa Dolatshahi, Farzaneh Rahmani, Paul K Commean, Sara Hosseinzadeh Kasani, Mahshid Naghashzadeh, LaKisha Lloyd, Caitlyn Nguyen, Abby McBee‐Kemper, Jake Weeks, Lael Ceriani, Bettina Mittendorfer, Claude Sirlin, Sheng‐Kwei Song, Tammie LS Benzinger, Joseph E Ippolito, John C Morris, Cyrus A Raji (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712834.txt.
Description
Mahsa Dolatshahi and a large team of co-authors test in 2025 whether liver fat links to brain inflammation in midlife obesity, a known risk factor for later Alzheimer's disease. Fat in organs raises body-wide inflammation and harms thinking. They scanned brains and abdomens of 67 cognitively normal middle-aged adults and measured insulin resistance for the analysis.
A trained neural network computed liver fat maps from standard MRI scans. A special diffusion method estimated brain tissue traits linked to inflammation and injury. Participants averaged about fifty years old, and over half had obesity. The study probes a liver-brain pathway that may matter for prevention.
Catalog record
| CREATOR | Mahsa Dolatshahi, Farzaneh Rahmani, Paul K Commean, Sara Hosseinzadeh Kasani, Mahshid Naghashzadeh, LaKisha Lloyd, Caitlyn Nguyen, Abby McBee‐Kemper, Jake Weeks, Lael Ceriani, Bettina Mittendorfer, Claude Sirlin, Sheng‐Kwei Song, Tammie LS Benzinger, Joseph E Ippolito, John C Morris, Cyrus A Raji |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |