Kinetic and X‐ray Structural Characterization of Phospholipase C Gamma 2 PLCG2–an Emerging Target for Alzheimer’s Disease
Bridget L Kaiser, Emma K Lendy, Nicolas Morato, Yunfei Feng, Daniel E Beck, Karson S Putt, Graham Cooks, Andrew D. Mesecar · 2025
Read Kinetic and X‐ray Structural Characterization of Phospholipase C Gamma 2 PLCG2–an Emerging Target for Alzheimer’s Disease by Bridget L Kaiser, Emma K Lendy, Nicolas Morato, Yunfei Feng, Daniel E Beck, Karson S Putt, Graham Cooks, Andrew D. Mesecar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712828.txt.
Description
Bridget Kaiser and seven co-authors report a 2025 conference study on an enzyme eyed as a drug target for Alzheimer's disease. The enzyme, PLCG2, works in microglia, the brain's immune cells, and helps them clear amyloid. A natural variant of the enzyme is more active and goes with lower disease risk, which makes boosting it an appealing plan.
The team made the enzyme in insect cells and measured how fast it works with two different tests, which agreed well. They also built structural models from X-ray and electron microscope data. The models show a sound active site holding a calcium atom, but one whole domain stayed blurry in both methods. That looseness may help the enzyme bind partners at the cell membrane. No full public structure existed before, so the work aids drug design.
Catalog record
| CREATOR | Bridget L Kaiser, Emma K Lendy, Nicolas Morato, Yunfei Feng, Daniel E Beck, Karson S Putt, Graham Cooks, Andrew D. Mesecar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |