Influence of tau pathology and anxiety and depressive symptoms on metamemory in cognitively normal older adults
Jennifer L. Crawford, Alex Adornato, Johanna Matulonis, Jacob M. Hooker, Anne S. Berry · 2025
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Description
Crawford and four co-authors study how older adults judge their own memory, in this 2025 paper. The skill, called metamemory, fades with age and fades more in Alzheimer's disease. Changes in it may warn of disease before symptoms show. The team asked whether mood and a disease-linked brain protein shape this self-judgment.
Forty-eight older adults with normal thinking took memory tests, filled in surveys on memory and mood, and had brain scans for the tau protein. Worse mood scores, not worse memory scores, tracked with poorer self-judgment. Tau in one deep brain region, the amygdala, sharpened that link: people with both high tau and low mood rated their memory worst. The authors argue that mood deserves a place in studies of early disease signs.
Catalog record
| CREATOR | Jennifer L. Crawford, Alex Adornato, Johanna Matulonis, Jacob M. Hooker, Anne S. Berry |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |