Differential associations between plasma p‐tau181 and hippocampal subfield integrity across the Alzheimer’s disease diagnostic continuum
Adea Rich, Hwamee Oh · 2025
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Description
Adea Rich and Hwamee Oh (2025) ask how a blood marker of Alzheimer's disease relates to fine-grained damage in the hippocampus, the brain's memory hub. The marker is p-tau181, a fragment of the tau protein measurable in plasma. Its link to cognition is established, but the brain mechanism in between is murky. The authors used data from a major Alzheimer's research cohort: 213 people, fifty-seven cognitively normal, 109 with mild impairment, and forty-seven with Alzheimer's dementia, each with blood measures and high-resolution brain scans.
Software divided each hippocampus into subfields, small zones with distinct jobs in memory. The team related marker levels to each subfield's volume, both at baseline and about a year later in a subset. They then tested whether subfield shrinkage explains the marker's tie to worse cognition, a mediation question. The answer would show which memory circuits a cheap blood test is silently reporting on.
Catalog record
| CREATOR | Adea Rich, Hwamee Oh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |