The role of biofluid markers in predicting near‐term cognitive impairment
Yara Yakoub, Fernando Gonzalez‐Ortiz, Nicholas J. Ashton, Thomas K Karikari, Cherie Strikwerda‐Brown, Frédéric St‐Onge, Valentin Ourry, Michael Schöll, Maiya R. Geddes, Simon Ducharme, Pedro Rosa‐Neto, Jean‐Paul Soucy, John C.S. Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villene · 2025
Read The role of biofluid markers in predicting near‐term cognitive impairment by Yara Yakoub, Fernando Gonzalez‐Ortiz, Nicholas J. Ashton, Thomas K Karikari, Cherie Strikwerda‐Brown, Frédéric St‐Onge, Valentin Ourry, Michael Schöll, Maiya R. Geddes, Simon Ducharme, Pedro Rosa‐Neto, Jean‐Paul Soucy, John C.S. Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villene (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712813.txt.
Description
Yara Yakoub and co-authors test whether blood and spinal fluid markers can flag healthy older adults headed for near term cognitive decline. Published in 2025, the study follows 218 unimpaired volunteers from the PREVENT-AD cohort for about five years on average. Plasma amyloid and tau markers were measured while all were still cognitively normal.
Marker positive plasma predicted progression to mild cognitive impairment, and the team repeated the test with spinal fluid and PET scan markers in smaller subgroups. Annual thinking tests tracked who declined. The search matters because brain scans that do this job are costly and scarce, while a blood draw is cheap. The authors frame fluid markers as a practical early warning for trials and clinics alike.
Catalog record
| CREATOR | Yara Yakoub, Fernando Gonzalez‐Ortiz, Nicholas J. Ashton, Thomas K Karikari, Cherie Strikwerda‐Brown, Frédéric St‐Onge, Valentin Ourry, Michael Schöll, Maiya R. Geddes, Simon Ducharme, Pedro Rosa‐Neto, Jean‐Paul Soucy, John C.S. Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villene |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |