Estimating the time between Aβ positivity and elevated regional tau in preclinical AD
William Coath, Tobey J. Betthauser, Jordan P Teague, Erik Arstad, Ramla Awais, Kerstin Sander, Catherine J Scott, David L Thomas, John Dickson, Pawel J Markiewicz, Frederik Barkhof, Michael Schöll, Marcus Richards, Nick C Fox, David M Cash, Jonathan M Schott · 2025
Read Estimating the time between Aβ positivity and elevated regional tau in preclinical AD by William Coath, Tobey J. Betthauser, Jordan P Teague, Erik Arstad, Ramla Awais, Kerstin Sander, Catherine J Scott, David L Thomas, John Dickson, Pawel J Markiewicz, Frederik Barkhof, Michael Schöll, Marcus Richards, Nick C Fox, David M Cash, Jonathan M Schott (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712810.txt.
Description
William Coath and co-authors estimate in 2025 how much time passes between two stages of Alzheimer's disease in people who still think clearly. First, a protein called amyloid turns positive on a brain scan. Later, a second protein, tau, rises in set brain regions. Knowing the gap between those steps matters for drugs that attack amyloid, since timing may decide how well they work.
The team used a British birth cohort of people born in 1946. Members had two amyloid scans, and a subgroup enriched for amyloid also had a tau scan. A changepoint model marked when each person's amyloid turned positive and when tau rose. The gap it gives can help trial teams pick who to treat and when. It also helps families and doctors read what a positive scan means for the years ahead.
Catalog record
| CREATOR | William Coath, Tobey J. Betthauser, Jordan P Teague, Erik Arstad, Ramla Awais, Kerstin Sander, Catherine J Scott, David L Thomas, John Dickson, Pawel J Markiewicz, Frederik Barkhof, Michael Schöll, Marcus Richards, Nick C Fox, David M Cash, Jonathan M Schott |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |