Polygenic score‐wide association study of comorbidities to incident dementia
Sang‐Hyuk Jung, Jakob Woerner, Dong‐gi Lee, Yonghyun Nam, Li Shen, Hong‐Hee Won, Dokyoon Kim · 2025
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Description
Sang-Hyuk Jung and co-authors published a research paper in 2025 on whether gene-based risk for other illnesses also raises the odds of dementia later in life. Many health troubles show up before dementia does. The team asked which of them share gene roots with it, using records from the UK Biobank.
They built gene scores for hundreds of illnesses and tested each against new dementia cases among more than 377,000 adults. Fifty-three scores held up after strict checks. Illnesses of the heart and blood, plus hormone and mood disorders, ranked highest. The results map which long-term ills may share biology with dementia, and which might be worth treating early to cut risk.
Catalog record
| CREATOR | Sang‐Hyuk Jung, Jakob Woerner, Dong‐gi Lee, Yonghyun Nam, Li Shen, Hong‐Hee Won, Dokyoon Kim |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |