Relationships Between Microbiome‐derived Short Chain Fatty Acids and Alzheimer’s Disease Pathology Biomarkers: A Human Cohort Study
Jessamine F Kuehn, Margo B Heston, Matthew F Warren, Jea Woo Kang, Sandra Harding, Nancy J Davenport‐Sis, Robert L Kerby, Emma C Schiffmann, Joseph L Wheeler, Hanna M Noughani, Allison A Forst, Grace Everitt, Sushma Shankar, Alissa Mickol, Justus Zemberi, Hana Chow, Eric Zhang, Eleanor Clements, Cyn · 2025
Read Relationships Between Microbiome‐derived Short Chain Fatty Acids and Alzheimer’s Disease Pathology Biomarkers: A Human Cohort Study by Jessamine F Kuehn, Margo B Heston, Matthew F Warren, Jea Woo Kang, Sandra Harding, Nancy J Davenport‐Sis, Robert L Kerby, Emma C Schiffmann, Joseph L Wheeler, Hanna M Noughani, Allison A Forst, Grace Everitt, Sushma Shankar, Alissa Mickol, Justus Zemberi, Hana Chow, Eric Zhang, Eleanor Clements, Cyn (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712807.txt.
Description
Jessamine Kuehn and co-authors test, in a 2025 study, how short fats made by gut germs link to marks of Alzheimer's disease in the brain. The fats, such as acetate and butyrate, form when germs ferment fiber in food. Proof hints they may touch key steps of the disease, but their role in people is not set. Stool samples came from 124 people in a study tied to two Wisconsin groups that track risk for the disease. A gas method read the fat levels in each sample.
The team then matched fat levels to brain marks of the disease in the same people. The cohorts are rich in risk for Alzheimer's, so marks can be seen before strong signs set in. The work adds human data to a field long based on animal tests. Its finds may guide diet or germ care trials.
Catalog record
| CREATOR | Jessamine F Kuehn, Margo B Heston, Matthew F Warren, Jea Woo Kang, Sandra Harding, Nancy J Davenport‐Sis, Robert L Kerby, Emma C Schiffmann, Joseph L Wheeler, Hanna M Noughani, Allison A Forst, Grace Everitt, Sushma Shankar, Alissa Mickol, Justus Zemberi, Hana Chow, Eric Zhang, Eleanor Clements, Cyn |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |