Characterization of cerebrospinal fluid tau MTBR species binding to Bepranemab
Nicolas R Barthélemy, Yingxin He, Brendan Androff, Yan Li, Thi Liên‐Anh Nguyên, Patrick Downey, Eric McDade, Randall J Bateman · 2025
Read Characterization of cerebrospinal fluid tau MTBR species binding to Bepranemab by Nicolas R Barthélemy, Yingxin He, Brendan Androff, Yan Li, Thi Liên‐Anh Nguyên, Patrick Downey, Eric McDade, Randall J Bateman (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712800.txt.
Description
Nicolas Barthélemy and co-authors characterised in 2025 which tau fragments in spinal fluid bind a candidate Alzheimer's antibody. The antibody, bepranemab, targets a stretch of the tau protein and blocks tau spread in cell and mouse studies. What it actually grabs in human fluid was unknown.
Using mass spectrometry on antibody-captured fluid, the team found mostly short tau fragments ending in the antibody's target region, with few pieces reaching the aggregate core. Samples came from inherited Alzheimer's mutation carriers, with and without symptoms, and from non-carriers. The pool of antibody-reactive fragments rose in carriers. The results clarify what the drug engages in people, a step toward judging its action.
Catalog record
| CREATOR | Nicolas R Barthélemy, Yingxin He, Brendan Androff, Yan Li, Thi Liên‐Anh Nguyên, Patrick Downey, Eric McDade, Randall J Bateman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |