Synthesis and biological evaluation of some novel coumarin‐oxadiazole conjugates as potential candidates for the treatment of cognitive decline
Geetakshi Arora, Poonam Piplani · 2025
Read Synthesis and biological evaluation of some novel coumarin‐oxadiazole conjugates as potential candidates for the treatment of cognitive decline by Geetakshi Arora, Poonam Piplani (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712799.txt.
Description
Geetakshi Arora and Poonam Piplani created in 2025 eight new hybrid molecules joining coumarin and oxadiazole parts, aiming at treatments for memory decline. They confirmed each structure with standard lab spectra. The compounds were first tested for blocking an enzyme that breaks down a key memory chemical in the brain.
Three compounds stood out. In mice given a drug that impairs memory, they improved performance in learning and avoidance tasks at a low dose. Tests on brain tissue confirmed enzyme blocking. The compounds also eased oxidative damage, raising protective enzyme levels and lowering harmful byproducts. The authors suggest the anti-amnesic effect combines support for the brain's chemical messaging with antioxidant action.
Catalog record
| CREATOR | Geetakshi Arora, Poonam Piplani |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |