Unraveling Alzheimer’s Disease Heterogeneity: A Comparative Analysis Using HYDRA and CHIMERA
Gordon An, Tammie LS Benzinger, Aristeidis Sotiras, Brian A Gordon · 2025
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Description
Gordon An, Tammie Benzinger, Aristeidis Sotiras, and Brian Gordon present a 2025 study comparing two methods that sort Alzheimer's disease into subtypes. The disease does not shrink the brain in one fixed pattern. Finding the true patterns could sharpen trials and tailor care, but the best tool for the job is unclear.
Both methods were run on brain scans from a public imaging project. One builds a shape with many flat faces, each face a disease pattern. The other tracks how a healthy brain pattern morphs into disease patterns along several paths. The paper weighs how each method draws the line between subtypes and what patterns each one finds.
Catalog record
| CREATOR | Gordon An, Tammie LS Benzinger, Aristeidis Sotiras, Brian A Gordon |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |