Structural Mechanism of γ‐secretase Cleavage and Regulation
Rui Zhou · 2025
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Description
Rui Zhou, writing alone, reviews the structure of gamma-secretase in this 2025 paper. This enzyme cuts proteins inside cell membranes. Its cuts on one target make the amyloid peptides that form plaques in Alzheimer disease.
More than three hundred disease mutations sit in presenilin, the cutting part of the enzyme. Drugs that block it have caused harsh side effects, likely by hitting other targets like Notch. Zhou's team solved shapes of the enzyme bound to each target type. The two targets bind in contrasting ways. Shapes with blockers and modulators show shared themes that could guide safer, target-selective drugs.
Catalog record
| CREATOR | Rui Zhou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |