NLRP3 regulates immunometabolism, impacting microglial function in Alzheimer’s disease
Roisin M. McManus, Max P Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Perea, Michelle‐Amirah Khalil, Johannes C.M. Schlachetzki, David S. Bouvier, Mario Lauterbach, Susanne V. Schmidt, David Gomez‐Cabrero, Jesper Tegner, Christopher K. Glass, Karsten Hiller, Eicke Latz, Mich · 2025
Read NLRP3 regulates immunometabolism, impacting microglial function in Alzheimer’s disease by Roisin M. McManus, Max P Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Perea, Michelle‐Amirah Khalil, Johannes C.M. Schlachetzki, David S. Bouvier, Mario Lauterbach, Susanne V. Schmidt, David Gomez‐Cabrero, Jesper Tegner, Christopher K. Glass, Karsten Hiller, Eicke Latz, Mich (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712767.txt.
Description
Roisin McManus and co-authors study an immune sensor that shapes how brain support cells use fuel in Alzheimer disease, in a 2025 paper. The sensor, NLRP3, triggers inflammation when it meets disease-linked peptides. Mice that model the disease but lack the sensor are protected from its brain harm, and the team ask what else changes without it.
Single-cell gene and access data found a distinct group of microglia, the brain immune cells, in protected mice. Those cells showed stronger eating of debris and a raised transporter for a brain chemical. Cells without the sensor also had better energy function and more of a key metabolite. That metabolite was required for their stronger clearing of amyloid, via control of gene switching. The pattern held in human cells, and drugs that block the sensor copied it in mice.
Catalog record
| CREATOR | Roisin M. McManus, Max P Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Perea, Michelle‐Amirah Khalil, Johannes C.M. Schlachetzki, David S. Bouvier, Mario Lauterbach, Susanne V. Schmidt, David Gomez‐Cabrero, Jesper Tegner, Christopher K. Glass, Karsten Hiller, Eicke Latz, Mich |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |