Does Neurodegeneration Lag Behind Tau Deposition in Alzheimer Dementia?
Ujashi Shah, Long Xie, Emily McGrew, David A Wolk, Sandhitsu R Das · 2025
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Description
Ujashi Shah and co-authors ask which comes first in Alzheimer's disease, tau tangles or brain shrinkage, in a 2025 study. The medial temporal lobe is among the first regions hit, and earlier hints suggested tangles gather before tissue loss shows. The team studied sixty-nine amyloid-positive patients with mild impairment or dementia, anchoring every scan to the date of each person's tau imaging.
Brain measures came from scans up to two years before and after that anchor: the size of the hippocampus and the thickness of one early-hit area, plus their yearly rates of loss. Cross-sectional links between tau and shrinkage were present and grew stronger at later time points, consistent with shrinkage lagging behind tau. Comparing the two kinds of measure was the study's core test.
Catalog record
| CREATOR | Ujashi Shah, Long Xie, Emily McGrew, David A Wolk, Sandhitsu R Das |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |