Mechanistic links of amyloid, atrophy, and cognition profiles for gait disturbance in Alzheimer’s disease
Min Seok Baek, Joon‐Kyung Seong, Sung‐Woo Kim, Dong Ho Kim, Jin Yong Hong · 2025
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Description
Min Seok Baek and co-authors study walking problems in Alzheimer's disease in this 2025 paper. Gait changes may track how the disease advances in the brain. The team enrolled patients with full dementia from the disease and patients at an earlier stage. A third group had no impairment of thinking. In all, more than one hundred people took part over about a year and a half. Each had brain scans, amyloid imaging, and tests of thinking and mood.
Walking was measured on a short mat fitted with pressure sensors. The team linked gait measures to skill scores and to amyloid load in brain regions. Thickness of the brain's outer layer in each region was also measured. A gene test for a known risk variant was included. The aim is a map of how walking, thinking, and brain change connect. Such a map could support earlier, fuller checks of patients.
Catalog record
| CREATOR | Min Seok Baek, Joon‐Kyung Seong, Sung‐Woo Kim, Dong Ho Kim, Jin Yong Hong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |