Significant changes in brain hemodynamic status in the presence of β‐amyloid deposition identified by Quantitative Gradient Recalled Echo (qGRE) MRI
Satya VVN Kothapalli, Tammie LS Benzinger, Andrew J Aschenbrenner, Cihat Eldeniz, John C Morris, Dmitriy A Yablonskiy · 2025
Read Significant changes in brain hemodynamic status in the presence of β‐amyloid deposition identified by Quantitative Gradient Recalled Echo (qGRE) MRI by Satya VVN Kothapalli, Tammie LS Benzinger, Andrew J Aschenbrenner, Cihat Eldeniz, John C Morris, Dmitriy A Yablonskiy (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712737.txt.
Description
Satya Kothapalli and co-authors read blood oxygen signals in the brain to flag Alzheimer pathology in a 2025 paper. Blood vessel trouble may be part of early Alzheimer disease, yet it is hard to measure. The team used a quantitative MRI method, qGRE, plus susceptibility maps from the same scan, in 105 older adults whose amyloid status was known.
People carrying excess brain amyloid showed more deoxygenated blood across the whole gray matter and in every lobe tested. Having a high level of that signal multiplied the odds of being amyloid positive about fivefold. Tissue properties shifted too, mainly in temporal and frontal lobes. The authors say pairing the two scan outputs can separate the blood signal from the tissue signal, sharpening non-invasive amyloid checks.
Catalog record
| CREATOR | Satya VVN Kothapalli, Tammie LS Benzinger, Andrew J Aschenbrenner, Cihat Eldeniz, John C Morris, Dmitriy A Yablonskiy |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |