Higher locus coeruleus integrity and cognitive reserve attenuate tau‐related cognitive decline in older adults
Lukas Heinrich, Joost M. Riphagen, Elouise A. Koops, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi I.L. Jacobs · 2025
Read Higher locus coeruleus integrity and cognitive reserve attenuate tau‐related cognitive decline in older adults by Lukas Heinrich, Joost M. Riphagen, Elouise A. Koops, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi I.L. Jacobs (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712728.txt.
Description
Lukas Heinrich and co-authors published a research paper in 2025 on a tiny brain stem hub that may help some older adults keep their thinking despite Alzheimer's changes. The hub is among the first places tau lands. People with rich schooling and work history also tend to hold up better, a shield known as cognitive reserve.
The team scanned 154 adults from a Harvard aging study and grouped them by reserve and disease load. In the high-load, high-reserve group, a sounder hub went with slower loss of thinking over time. The result ties the hub to the reserve effect in living people. It hints that guarding this small hub could matter a lot.
Catalog record
| CREATOR | Lukas Heinrich, Joost M. Riphagen, Elouise A. Koops, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi I.L. Jacobs |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |