Plasma GFAP, cortical amyloid, and cortical tau interact to predict neuroinflammatory changes within Alzheimer’s‐relevant white matter bundles
Brandon J Hall, Nesrine Rahmouni, Arnaud Boré, Seyyed Ali Hosseini, Joseph Therriault, Arthur C Macedo, Lydia Trudel, Tevy Chan, Firoza Z Lussier, Yi‐Ting Wang, Stijn Servaes, Etienne Aumont, Jaime Fernandez Arias, Yansheng Zheng, Cécile Tissot, Jenna Stevenson, Tharick A Pascoal, Nicholas J Ashton, · 2025
Read Plasma GFAP, cortical amyloid, and cortical tau interact to predict neuroinflammatory changes within Alzheimer’s‐relevant white matter bundles by Brandon J Hall, Nesrine Rahmouni, Arnaud Boré, Seyyed Ali Hosseini, Joseph Therriault, Arthur C Macedo, Lydia Trudel, Tevy Chan, Firoza Z Lussier, Yi‐Ting Wang, Stijn Servaes, Etienne Aumont, Jaime Fernandez Arias, Yansheng Zheng, Cécile Tissot, Jenna Stevenson, Tharick A Pascoal, Nicholas J Ashton, (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712701.txt.
Description
Hall and co-authors test how a blood marker of brain support cell stress interacts with amyloid and tau to forecast white matter inflammation. Their 2025 study follows 182 people with blood tests, gene typing, brain scans, and repeat diffusion imaging over about a year. Four memory-linked white matter bundles are tracked.
The marker, plasma GFAP, reflects astrocyte activation. Free water inside voxels serves as the inflammation-linked change signal. Regression models weigh the marker alone and crossed with amyloid and tau status. About two in five participants carry the risk gene variant; seventy are amyloid positive. The authors argue single markers under-read Alzheimer change, and that glial, amyloid, and tau signals must be read together to see white matter risk early.
Catalog record
| CREATOR | Brandon J Hall, Nesrine Rahmouni, Arnaud Boré, Seyyed Ali Hosseini, Joseph Therriault, Arthur C Macedo, Lydia Trudel, Tevy Chan, Firoza Z Lussier, Yi‐Ting Wang, Stijn Servaes, Etienne Aumont, Jaime Fernandez Arias, Yansheng Zheng, Cécile Tissot, Jenna Stevenson, Tharick A Pascoal, Nicholas J Ashton, |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |