Heneicosapentaenoic acid, a metabolite resulting from the α‐oxidation of α‐Hydroxy‐Docosahexaenoic Acid, exerts neuroprotection against Alzheimer’s disease and reduces astrocytic mitochondrial activity
Joan Cabot, Sebastià Parets, Marc Miralles, Laura Trujillo‐Estrada, Antonia Gutierrez, Paula Fernández‐García, Victoria Lladó, Pablo V Escriba, Manuel Torres · 2025
Read Heneicosapentaenoic acid, a metabolite resulting from the α‐oxidation of α‐Hydroxy‐Docosahexaenoic Acid, exerts neuroprotection against Alzheimer’s disease and reduces astrocytic mitochondrial activity by Joan Cabot, Sebastià Parets, Marc Miralles, Laura Trujillo‐Estrada, Antonia Gutierrez, Paula Fernández‐García, Victoria Lladó, Pablo V Escriba, Manuel Torres (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712663.txt.
Description
Joan Cabot and co-authors published a research paper in 2025 on a fat-based compound and the breakdown product that may carry its brain-guarding effect. The source compound, built from a fish oil fat, had already helped cells and mice with Alzheimer's-like changes. Inside the body it is trimmed into a shorter fat, and the team tested that product head-on.
Mice bred for the disease got daily doses by mouth for four months, then ran a maze test. Both the source and its product were tracked in cells and in the mice. The product shielded nerve cells from a toxic flood of signals and calmed the power plants of support cells. The work pins down which form does the guarding.
Catalog record
| CREATOR | Joan Cabot, Sebastià Parets, Marc Miralles, Laura Trujillo‐Estrada, Antonia Gutierrez, Paula Fernández‐García, Victoria Lladó, Pablo V Escriba, Manuel Torres |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |