The Common Marmoset as a Preclinical Primate Model for Alzheimer’s disease
Afonso C Silva · 2025
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Description
Afonso Silva reviews in 2025 an effort to model Alzheimer's disease in common marmosets, small primates closer to humans than rodents. Mouse models miss primate-specific roots of the disease, a gap blamed for failed treatments. A consortium used gene editing to create marmosets carrying mutations in a gene tied to early Alzheimer's. The edited founders are viable, and one line already passes the mutation to offspring.
Long-term tracking of the models and of normally aging marmosets is under way. All data and resources will be shared openly with the field. Silva argues such models can reveal the cellular triggers of the disease. That could speed therapies toward patients.
Catalog record
| CREATOR | Afonso C Silva |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |